Saturday's visitors to the Memorial Stadium have been struggling to adjust to life in League One following their promotion last season.
Derek Adams men have only picked up one win in the league this season, beating Charlton Athletic at Home Park back at the start of August.
Currently sitting at the bottom of League One, here are the players to look out for at the Mem this Saturday.
Graham Carey - Midfielder
Graham Carey [pictured above] signed for Derek Adams for the second time in his career in 2015 after a previous spell with Argyle’s manager at Ross County and went on to be named 2015-2016 Pilgrim of the Year.
Last season, Carey led the Pilgrims to second place in League Two, securing the Greens a League One promotion where he made the most appearances for the club – 53 – adding an impressive 15 goals to his name.
Although, he has only scored once this season, Carey will be the main man to watch come 3pm.
Gregg Wylde - Midfielder
Scottish winger Wylde [pictured above] rejoined the Pilgrims in the summer following a season in League One with Millwall and Northampton Town, who he played for on loan from the Den.
After joining Millwall last summer, he made just 10 appearances for the Lions before moving on loan to Northampton.
He played 12 times for the Cobblers before needing surgery on a groin injury, from which he is now recovered, and his Millwall contract was terminated by mutual consent in May.
Nathan Blissett - Striker
A potential fan favourite amongst many of the Rovers faithful following a spell at the club. He was part of the Rovers team promoted to the EFL in 2014-15, then had loan spells at Tranmere Rovers and Lincoln City before arriving in Devon.
Nathan became the first player that Argyle had paid a fee for in nearly five years when he camed to Home Park in the January transfer window of the 2016-2017 season
Nathan made his way from South to West Devon, leaving Torquay in favour of Argyle, having scored 12 goals in 41 appearances for the Gulls since signing for them in January 2016.