Clarke, Lockyer, Beardsley and Gillespie in the starting line up
John Ward has made four changes to the side that lost to Hartlepool last weekend.
Steven Gillespie makes his first start for Bristol Rovers, partnering Chris Beardsley up front.
Tom Lockyer and Ollie Clarke are both recalled to midfield. Matt Harrold, David Clarkson, Danny Woodards and Seanan Clucas all drop to the bench.
Rovers: Steve Mildenhall, Michael Smith, Tom Parkes, Mark McChrystal, Lee Brown, Kaid Mohamed, Tom Lockyer. Ollie Clarke, John-Joe O’Toole, Chris Beardsley, Steven Gillespie
Substitutes: Danny Woodards, David Clarkson, Matt Harrold, Ellis Harrison, Conor Gough, Seanan Clucas, Alefe Santos
Southend: Daniel Bentley, John White, Ben Coker, Freddie Eastwood, Michael Timlin, Will Atkinson, Kevan Hurst, Ryan Leonard, John Egan, Jakub Sokolik, Lee Barnard.
Substitutes: Paul Smith, Luke Prosser, Jamar Loza, Anthony Straker, Conor Clifford, Jack Payne, Bedsente Gomis