Angelo Balanta, Bradley Goldberg and new loan goalkeeper Fabian Spiess come in to make their full debuts and Ollie Clarke returns to the starting 11 following injury.
Darrell has decided to change the formation of his side playing 3-4-3 with Angelo Balanta sitting behind the front two of Blissett and Goldberg.
The Rovers boss said "I wanted to freshen things up, it is a system that we have played before this season and have been comfortable with it.
"Angelo will play in behind the two forwards with Lockyer, McChrystal and Parkes making up a back three.
Rovers: Fabian Spiess, Tom Lockyer, Mark McChrystal (C), Tom Parkes, Stuart Sinclair, Ollie Clarke, Lee Mansell, Lee Brown, Angelo Balanta, Nathan Blissett, Bradley Goldberg.
Substitutes: Daniel Leadbitter, Neal Trotman, Jake Gosling, Alex Wall, Matty Taylor.