Rovers make four changes to the side that lost to Gillingham on Saturday.
Matt Harrold misses through his injury and Michael Smith, Eliiot Richards and Jim Paterson also miss out.
Garry Kenneth and Fabian Borghammer make their full debuts for the club.
Bristol Rovers: Sam Walker, Adam Virgo, Garry Kenneth, Tom Parkes, Lee Brown, Wayne Brown, Matt Gill, Fabian Broghammer, Oliver Norburn, Matt Lund, David Clarkson.
Subs: Michael Smith, Conor Gough, Jim Paterson, Eliot Richards, Joe Anyinsah, Ollie Clarke, Seanan Clucas
Plymouth: Jake Cole, Durrell Berry, Darren Purse, Maxime Blanchard, Robbie Williams, Alex MacDonald, Luke Young, Conor Hourihane, Onismor Bhasera, Matt Leconite, Guy Madjo.
Subs: Ollie Chenoweth, Curtis Nelson, Joe Lennox, Paris Cowan-Hall, Warren Feeney, Andres Gurrieri, Jonny Gorman.